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Sensitivity and Uncertainty Analysis of Two Human Atrial Cardiac Cell Models Using Gaussian Process Emulators

Biophysically detailed cardiac cell models reconstruct the action potential and calcium dynamics of cardiac myocytes. They aim to capture the biophysics of current flow through ion channels, pumps, and exchangers in the cell membrane, and are highly detailed. However, the relationship between model...

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Detalles Bibliográficos
Autores principales: Coveney, Sam, Clayton, Richard H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191317/
https://www.ncbi.nlm.nih.gov/pubmed/32390867
http://dx.doi.org/10.3389/fphys.2020.00364