Small Alphaherpesvirus Latency-Associated Promoters Drive Efficient and Long-Term Transgene Expression in the CNS

Recombinant adeno-associated viruses (rAAVs) are used as gene therapy vectors to treat central nervous system (CNS) diseases. Despite their safety and broad tropism, important issues need to be corrected such as the limited payload capacity and the lack of small gene promoters providing long-term, p...

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Detalles Bibliográficos
Autores principales: Maturana, Carola J., Verpeut, Jessica L., Pisano, Thomas J., Dhanerawala, Zahra M., Esteves, Andrew, Enquist, Lynn W., Engel, Esteban A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191541/
https://www.ncbi.nlm.nih.gov/pubmed/32368565
http://dx.doi.org/10.1016/j.omtm.2020.04.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191541/
https://www.ncbi.nlm.nih.gov/pubmed/32368565
http://dx.doi.org/10.1016/j.omtm.2020.04.004

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