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Comparative effects of oncogenic mutations G12C, G12V, G13D, and Q61H on local conformations and dynamics of K-Ras

K-Ras is the most frequently mutated protein in human cancers. However, until very recently, its oncogenic mutants were viewed as undruggable. To develop inhibitors that directly target oncogenic K-Ras mutants, we need to understand both their mutant-specific and pan-mutant dynamics and conformation...

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Detalles Bibliográficos
Autores principales: Vatansever, Sezen, Erman, Burak, Gümüş, Zeynep H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191603/
https://www.ncbi.nlm.nih.gov/pubmed/32373288
http://dx.doi.org/10.1016/j.csbj.2020.04.003