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IP(3)-Dependent Ca(2+) Oscillations Switch into a Dual Oscillator Mechanism in the Presence of PLC-Linked Hormones

Ca(2+) oscillations that depend on inositol-1,4,5-trisphosphate (IP(3)) have been ascribed to biphasic Ca(2+) regulation of the IP(3) receptor (IP(3)R) or feedback mechanisms controlling IP(3) levels in different cell types. IP(3) uncaging in hepatocytes elicits Ca(2+) transients that are often loca...

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Detalles Bibliográficos
Autores principales: Bartlett, Paula J., Cloete, Ielyaas, Sneyd, James, Thomas, Andrew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191650/
https://www.ncbi.nlm.nih.gov/pubmed/32353764
http://dx.doi.org/10.1016/j.isci.2020.101062