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Diffusion Behavior of Drug Molecules in Acrylic Pressure-Sensitive Adhesive

[Image: see text] Acrylic pressure-sensitive adhesive (PSA) is widely used in transdermal drug delivery systems, while the diffusion behavior of drug molecules in PSA is of great importance. In this paper, PSAs with different cross-link densities were prepared by adjusting the ratio of cross-linkers...

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Autores principales: Chen, Xuexue, Wang, Yaxin, Cheng, Zhipeng, Wei, Jie, Shi, Yifeng, Qian, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191847/
https://www.ncbi.nlm.nih.gov/pubmed/32363293
http://dx.doi.org/10.1021/acsomega.0c00491
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author Chen, Xuexue
Wang, Yaxin
Cheng, Zhipeng
Wei, Jie
Shi, Yifeng
Qian, Jun
author_facet Chen, Xuexue
Wang, Yaxin
Cheng, Zhipeng
Wei, Jie
Shi, Yifeng
Qian, Jun
author_sort Chen, Xuexue
collection PubMed
description [Image: see text] Acrylic pressure-sensitive adhesive (PSA) is widely used in transdermal drug delivery systems, while the diffusion behavior of drug molecules in PSA is of great importance. In this paper, PSAs with different cross-link densities were prepared by adjusting the ratio of cross-linkers. The effects of cross-link density and temperature on the diffusion of drugs in PSA were investigated by Fourier transform infrared attenuated total reflectance and molecular dynamics simulation. The consistency between the experimental and simulation results demonstrated that molecular dynamics simulation could be used to predict the diffusion behavior of drugs in PSA. The results showed that free volume and the wriggling of polymer chains are positively related to the diffusion coefficient of drug molecules, while hydrogen bonds hinder drug diffusion.
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spelling pubmed-71918472020-05-01 Diffusion Behavior of Drug Molecules in Acrylic Pressure-Sensitive Adhesive Chen, Xuexue Wang, Yaxin Cheng, Zhipeng Wei, Jie Shi, Yifeng Qian, Jun ACS Omega [Image: see text] Acrylic pressure-sensitive adhesive (PSA) is widely used in transdermal drug delivery systems, while the diffusion behavior of drug molecules in PSA is of great importance. In this paper, PSAs with different cross-link densities were prepared by adjusting the ratio of cross-linkers. The effects of cross-link density and temperature on the diffusion of drugs in PSA were investigated by Fourier transform infrared attenuated total reflectance and molecular dynamics simulation. The consistency between the experimental and simulation results demonstrated that molecular dynamics simulation could be used to predict the diffusion behavior of drugs in PSA. The results showed that free volume and the wriggling of polymer chains are positively related to the diffusion coefficient of drug molecules, while hydrogen bonds hinder drug diffusion. American Chemical Society 2020-04-16 /pmc/articles/PMC7191847/ /pubmed/32363293 http://dx.doi.org/10.1021/acsomega.0c00491 Text en Copyright © 2020 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Chen, Xuexue
Wang, Yaxin
Cheng, Zhipeng
Wei, Jie
Shi, Yifeng
Qian, Jun
Diffusion Behavior of Drug Molecules in Acrylic Pressure-Sensitive Adhesive
title Diffusion Behavior of Drug Molecules in Acrylic Pressure-Sensitive Adhesive
title_full Diffusion Behavior of Drug Molecules in Acrylic Pressure-Sensitive Adhesive
title_fullStr Diffusion Behavior of Drug Molecules in Acrylic Pressure-Sensitive Adhesive
title_full_unstemmed Diffusion Behavior of Drug Molecules in Acrylic Pressure-Sensitive Adhesive
title_short Diffusion Behavior of Drug Molecules in Acrylic Pressure-Sensitive Adhesive
title_sort diffusion behavior of drug molecules in acrylic pressure-sensitive adhesive
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191847/
https://www.ncbi.nlm.nih.gov/pubmed/32363293
http://dx.doi.org/10.1021/acsomega.0c00491
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