Hybrid inhibitors of DNA and HDACs remarkably enhance cytotoxicity in leukaemia cells

Chlorambucil is a nitrogen mustard-based DNA alkylating drug, which is widely used as a front-line treatment of chronic lymphocytic leukaemia (CLL). Despite its widespread application and success for the initial treatment of leukaemia, a majority of patients eventually develop acquired resistance to...

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Detalles Bibliográficos
Autores principales: Song, Yoojin, Park, Sun You, Wu, Zhexue, Liu, Kwang-Hyeon, Seo, Young Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191901/
https://www.ncbi.nlm.nih.gov/pubmed/32314611
http://dx.doi.org/10.1080/14756366.2020.1754812

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191901/
https://www.ncbi.nlm.nih.gov/pubmed/32314611
http://dx.doi.org/10.1080/14756366.2020.1754812

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