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Hybrid inhibitors of DNA and HDACs remarkably enhance cytotoxicity in leukaemia cells
Chlorambucil is a nitrogen mustard-based DNA alkylating drug, which is widely used as a front-line treatment of chronic lymphocytic leukaemia (CLL). Despite its widespread application and success for the initial treatment of leukaemia, a majority of patients eventually develop acquired resistance to...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191901/ https://www.ncbi.nlm.nih.gov/pubmed/32314611 http://dx.doi.org/10.1080/14756366.2020.1754812 |