Uricase-deficient rat is generated with CRISPR/Cas9 technique

Urate oxidase (uricase, Uox) is a big obstacle for scientists to establish stable animal models for studying hyperuricemia and associated disorders. Due to the low survival rate of uricase-deficient mice, we generated a Uox-knockout model animal from Sprague Dawley (SD) rats using the CRISPR/Cas9 te...

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Detalles Bibliográficos
Autores principales: Yu, Yun, Zhang, Nan, Dong, Xianxiang, Fan, Nan, Wang, Lei, Xu, Yuhui, Chen, Huan, Duan, Weigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2020
Materias:
Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192158/
https://www.ncbi.nlm.nih.gov/pubmed/32368418
http://dx.doi.org/10.7717/peerj.8971

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192158/
https://www.ncbi.nlm.nih.gov/pubmed/32368418
http://dx.doi.org/10.7717/peerj.8971

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