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Uricase-deficient rat is generated with CRISPR/Cas9 technique
Urate oxidase (uricase, Uox) is a big obstacle for scientists to establish stable animal models for studying hyperuricemia and associated disorders. Due to the low survival rate of uricase-deficient mice, we generated a Uox-knockout model animal from Sprague Dawley (SD) rats using the CRISPR/Cas9 te...
Autores principales: | Yu, Yun, Zhang, Nan, Dong, Xianxiang, Fan, Nan, Wang, Lei, Xu, Yuhui, Chen, Huan, Duan, Weigang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PeerJ Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192158/ https://www.ncbi.nlm.nih.gov/pubmed/32368418 http://dx.doi.org/10.7717/peerj.8971 |
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