Effect of linker on the binding free energy of stapled p53/HDM2 complex

Inactivation of the tumor suppressor p53 resulting from the binding with a negative regulator HDM2 is among the predominant defects in human cancers. p53-mimicking peptides whose conformational and proteolytic stability is enhanced by an all-hydrocarbon staple are being recognized as promising antic...

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Detalles Bibliográficos
Autores principales: Im, Haeri, Ham, Sihyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192472/
https://www.ncbi.nlm.nih.gov/pubmed/32353067
http://dx.doi.org/10.1371/journal.pone.0232613