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Effect of linker on the binding free energy of stapled p53/HDM2 complex
Inactivation of the tumor suppressor p53 resulting from the binding with a negative regulator HDM2 is among the predominant defects in human cancers. p53-mimicking peptides whose conformational and proteolytic stability is enhanced by an all-hydrocarbon staple are being recognized as promising antic...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192472/ https://www.ncbi.nlm.nih.gov/pubmed/32353067 http://dx.doi.org/10.1371/journal.pone.0232613 |