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Eliciting priors and relaxing the single causal variant assumption in colocalisation analyses
Horizontal integration of summary statistics from different GWAS traits can be used to evaluate evidence for their shared genetic causality. One popular method to do this is a Bayesian method, coloc, which is attractive in requiring only GWAS summary statistics and no linkage disequilibrium estimate...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192519/ https://www.ncbi.nlm.nih.gov/pubmed/32310995 http://dx.doi.org/10.1371/journal.pgen.1008720 |