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Eliciting priors and relaxing the single causal variant assumption in colocalisation analyses

Horizontal integration of summary statistics from different GWAS traits can be used to evaluate evidence for their shared genetic causality. One popular method to do this is a Bayesian method, coloc, which is attractive in requiring only GWAS summary statistics and no linkage disequilibrium estimate...

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Detalles Bibliográficos
Autor principal:	Wallace, Chris
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192519/ https://www.ncbi.nlm.nih.gov/pubmed/32310995 http://dx.doi.org/10.1371/journal.pgen.1008720

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