Mechanistic insights from structure of Mycobacterium smegmatis topoisomerase I with ssDNA bound to both N- and C-terminal domains

Type IA topoisomerases interact with G-strand and T-strand ssDNA to regulate DNA topology. However, simultaneous binding of two ssDNA segments to a type IA topoisomerase has not been observed previously. We report here the crystal structure of a type IA topoisomerase with ssDNA segments bound in opp...

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Detalles Bibliográficos
Autores principales: Cao, Nan, Tan, Kemin, Zuo, Xiaobing, Annamalai, Thirunavukkarasu, Tse-Dinh, Yuk-Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192597/
https://www.ncbi.nlm.nih.gov/pubmed/32232337
http://dx.doi.org/10.1093/nar/gkaa201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192597/
https://www.ncbi.nlm.nih.gov/pubmed/32232337
http://dx.doi.org/10.1093/nar/gkaa201

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