G-quadruplex ligands mediate downregulation of DUX4 expression

Abnormal DUX4 expression in skeletal muscles plays a key role in facioscapulohumeral muscular dystrophy (FSHD) pathogenesis, although the molecular mechanisms regulating DUX4 expression are not fully defined. Using bioinformatic analysis of the genomic DUX4 locus, we have identified a number of puta...

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Detalles Bibliográficos
Autores principales: Ciszewski, Lukasz, Lu-Nguyen, Ngoc, Slater, Alex, Brennan, Andrew, Williams, Huw E L, Dickson, George, Searle, Mark S, Popplewell, Linda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192601/
https://www.ncbi.nlm.nih.gov/pubmed/32182342
http://dx.doi.org/10.1093/nar/gkaa146

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192601/
https://www.ncbi.nlm.nih.gov/pubmed/32182342
http://dx.doi.org/10.1093/nar/gkaa146

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