Enhanced affinity of racemic phosphorothioate DNA with transcription factor SATB1 arising from diastereomer-specific hydrogen bonds and hydrophobic contacts

Phosphorothioate modification is commonly introduced into therapeutic oligonucleotides, typically as a racemic mixture in which either of the two non-bridging phosphate oxygens is replaced by sulfur, which frequently increases affinities with proteins. Here, we used isothermal titration calorimetry...

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Detalles Bibliográficos
Autores principales: Yamasaki, Kazuhiko, Akutsu, Yukie, Yamasaki, Tomoko, Miyagishi, Makoto, Kubota, Tomomi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192603/
https://www.ncbi.nlm.nih.gov/pubmed/32187371
http://dx.doi.org/10.1093/nar/gkaa170

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192603/
https://www.ncbi.nlm.nih.gov/pubmed/32187371
http://dx.doi.org/10.1093/nar/gkaa170

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