High density of unrepaired genomic ribonucleotides leads to Topoisomerase 1-mediated severe growth defects in absence of ribonucleotide reductase

Cellular levels of ribonucleoside triphosphates (rNTPs) are much higher than those of deoxyribonucleoside triphosphates (dNTPs), thereby influencing the frequency of incorporation of ribonucleoside monophosphates (rNMPs) by DNA polymerases (Pol) into DNA. RNase H2-initiated ribonucleotide excision r...

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Detalles Bibliográficos
Autores principales: Cerritelli, Susana M, Iranzo, Jaime, Sharma, Sushma, Chabes, Andrei, Crouch, Robert J, Tollervey, David, El Hage, Aziz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192613/
https://www.ncbi.nlm.nih.gov/pubmed/32187369
http://dx.doi.org/10.1093/nar/gkaa103

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192613/
https://www.ncbi.nlm.nih.gov/pubmed/32187369
http://dx.doi.org/10.1093/nar/gkaa103

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