Cargando…

High density of unrepaired genomic ribonucleotides leads to Topoisomerase 1-mediated severe growth defects in absence of ribonucleotide reductase

Cellular levels of ribonucleoside triphosphates (rNTPs) are much higher than those of deoxyribonucleoside triphosphates (dNTPs), thereby influencing the frequency of incorporation of ribonucleoside monophosphates (rNMPs) by DNA polymerases (Pol) into DNA. RNase H2-initiated ribonucleotide excision r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cerritelli, Susana M, Iranzo, Jaime, Sharma, Sushma, Chabes, Andrei, Crouch, Robert J, Tollervey, David, El Hage, Aziz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192613/ https://www.ncbi.nlm.nih.gov/pubmed/32187369 http://dx.doi.org/10.1093/nar/gkaa103

Ejemplares similares

A genetic screen pinpoints ribonucleotide reductase residues that sustain dNTP homeostasis and specifies a highly mutagenic type of dNTP imbalance
por: Schmidt, Tobias T, et al.
Publicado: (2019)

The ribonucleotide reductase inhibitor, Sml1, is sequentially phosphorylated, ubiquitylated and degraded in response to DNA damage
por: Andreson, Bethany L., et al.
Publicado: (2010)

Topoisomerase 1-dependent deletions initiated by incision at ribonucleotides are biased to the non-transcribed strand of a highly activated reporter
por: Cho, Jang-Eun, et al.
Publicado: (2015)

Assembly of a fragmented ribonucleotide reductase by protein interaction domains derived from a mobile genetic element
por: Crona, Mikael, et al.
Publicado: (2011)

Hug1 is an intrinsically disordered protein that inhibits ribonucleotide reductase activity by directly binding Rnr2 subunit
por: Meurisse, Julie, et al.
Publicado: (2014)

Abasic and oxidized ribonucleotides embedded in DNA are processed by human APE1 and not by RNase H2
por: Malfatti, Matilde Clarissa, et al.
Publicado: (2017)

A polar filter in DNA polymerases prevents ribonucleotide incorporation
por: Johnson, Mary K, et al.
Publicado: (2019)

Parallel analysis of ribonucleotide-dependent deletions produced by yeast Top1 in vitro and in vivo
por: Cho, Jang-Eun, et al.
Publicado: (2016)

Aberrant ribonucleotide incorporation and multiple deletions in mitochondrial DNA of the murine MPV17 disease model
por: Moss, Chloe F., et al.
Publicado: (2017)

Ribonucleotide incorporation by human DNA polymerase η impacts translesion synthesis and RNase H2 activity
por: Mentegari, Elisa, et al.
Publicado: (2017)

Novel alternative ribonucleotide excision repair pathways in human cells by DDX3X and specialized DNA polymerases
por: Riva, Valentina, et al.
Publicado: (2020)

Novel ribonucleotide discrimination in the RNA polymerase-like two-barrel catalytic core of Family D DNA polymerases
por: Zatopek, Kelly M, et al.
Publicado: (2020)

Ribodysgenesis: sudden genome instability in the yeast Saccharomyces cerevisiae arising from RNase H2 cleavage at genomic-embedded ribonucleotides
por: Sui, Yang, et al.
Publicado: (2022)

Characterization of three mycobacterial DinB (DNA polymerase IV) paralogs highlights DinB2 as naturally adept at ribonucleotide incorporation
por: Ordonez, Heather, et al.
Publicado: (2014)

Effects of DNA(3′)pp(5′)G capping on 3′ end repair reactions and of an embedded pyrophosphate-linked guanylate on ribonucleotide surveillance
por: Chauleau, Mathieu, et al.
Publicado: (2015)

Stoichiometry of MutS and MutL at unrepaired mismatches in vivo suggests a mechanism of repair
por: Elez, Marina, et al.
Publicado: (2012)

TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1
por: Zeng, Zhihong, et al.
Publicado: (2012)

Pre-activation of the genome integrity checkpoint increases DNA damage tolerance
por: Tsaponina, Olga, et al.
Publicado: (2013)

RNase H2 roles in genome integrity revealed by unlinking its activities
por: Chon, Hyongi, et al.
Publicado: (2013)

Inactivation of folylpolyglutamate synthetase Met7 results in genome instability driven by an increased dUTP/dTTP ratio
por: Schmidt, Tobias T, et al.
Publicado: (2020)

Highly mutagenic and severely imbalanced dNTP pools can escape detection by the S-phase checkpoint
por: Kumar, Dinesh, et al.
Publicado: (2010)

Hydroxyurea-Mediated Cytotoxicity Without Inhibition of Ribonucleotide Reductase
por: Liew, Li Phing, et al.
Publicado: (2016)

Evidence for lesion bypass by yeast replicative DNA polymerases during DNA damage
por: Sabouri, Nasim, et al.
Publicado: (2008)

Adaptation of topoisomerase I paralogs to nuclear and mitochondrial DNA
por: Rosa, Ilaria Dalla, et al.
Publicado: (2009)

Condensin aids sister chromatid decatenation by topoisomerase II
por: Charbin, Adrian, et al.
Publicado: (2014)

Genome-wide analysis of the specificity and mechanisms of replication infidelity driven by imbalanced dNTP pools
por: Watt, Danielle L., et al.
Publicado: (2016)

Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools
por: Kumar, Dinesh, et al.
Publicado: (2011)

Spartan deficiency causes accumulation of Topoisomerase 1 cleavage complexes and tumorigenesis
por: Maskey, Reeja S., et al.
Publicado: (2017)

The MukB-topoisomerase IV interaction mutually suppresses their catalytic activities
por: Kumar, Rupesh, et al.
Publicado: (2021)

The α isoform of topoisomerase II is required for hypercompaction of mitotic chromosomes in human cells
por: Farr, Christine J., et al.
Publicado: (2014)

Topoisomerase II contributes to DNA secondary structure-mediated double-stranded breaks
por: Szlachta, Karol, et al.
Publicado: (2020)

Repeat expansion in the budding yeast ribosomal DNA can occur independently of the canonical homologous recombination machinery
por: Houseley, Jonathan, et al.
Publicado: (2011)

Telomere length kinetics assay (TELKA) sorts the telomere length maintenance (tlm) mutants into functional groups
por: Rubinstein, Linda, et al.
Publicado: (2014)

Phosphines are ribonucleotide reductase reductants that act via C-terminal cysteines similar to thioredoxins and glutaredoxins
por: Domkin, Vladimir, et al.
Publicado: (2014)

RECQL5 cooperates with Topoisomerase II alpha in DNA decatenation and cell cycle progression
por: Ramamoorthy, Mahesh, et al.
Publicado: (2012)

PARP1–TDP1 coupling for the repair of topoisomerase I–induced DNA damage
por: Das, Benu Brata, et al.
Publicado: (2014)

Yeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrations
por: Kochenova, Olga V., et al.
Publicado: (2017)

Novel TDP2-ubiquitin interactions and their importance for the repair of topoisomerase II-mediated DNA damage
por: Rao, Timsi, et al.
Publicado: (2016)

PRMT5-mediated arginine methylation of TDP1 for the repair of topoisomerase I covalent complexes
por: Rehman, Ishita, et al.
Publicado: (2018)

DNA topoisomerase IIα controls replication origin cluster licensing and firing time in Xenopus egg extracts
por: Gaggioli, Vincent, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_d8g3mcplbf7loaqgh34squqk77