Ectopic RNF168 expression promotes break-induced replication-like DNA synthesis at stalled replication forks

The RNF168 E3 ubiquitin ligase is activated in response to double stranded DNA breaks (DSBs) where it mono-ubiquitinates γH2AX (ub-H2AX). RNF168 protein expression and ubiquitin signaling are finely regulated during the sensing, repair and resolution of DNA damage in order to avoid excessive spreadi...

Descripción completa

Detalles Bibliográficos
Autores principales: Krais, John J, Johnson, Neil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192614/
https://www.ncbi.nlm.nih.gov/pubmed/32182354
http://dx.doi.org/10.1093/nar/gkaa154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192614/
https://www.ncbi.nlm.nih.gov/pubmed/32182354
http://dx.doi.org/10.1093/nar/gkaa154

Ejemplares similares