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Ectopic RNF168 expression promotes break-induced replication-like DNA synthesis at stalled replication forks
The RNF168 E3 ubiquitin ligase is activated in response to double stranded DNA breaks (DSBs) where it mono-ubiquitinates γH2AX (ub-H2AX). RNF168 protein expression and ubiquitin signaling are finely regulated during the sensing, repair and resolution of DNA damage in order to avoid excessive spreadi...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192614/ https://www.ncbi.nlm.nih.gov/pubmed/32182354 http://dx.doi.org/10.1093/nar/gkaa154 |