Mechanisms of palmitic acid-conjugated antisense oligonucleotide distribution in mice

Conjugation of antisense oligonucleotide (ASO) with a variety of distinct lipophilic moieties like fatty acids and cholesterol increases ASO accumulation and activity in multiple tissues. While lipid conjugation increases tissue exposure in mice and reduces excretion of ASO in urine, histological re...

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Detalles Bibliográficos
Autores principales: Chappell, Alfred E, Gaus, Hans J, Berdeja, Andres, Gupta, Ruchi, Jo, Minji, Prakash, Thazha P, Oestergaard, Michael, Swayze, Eric E, Seth, Punit P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192618/
https://www.ncbi.nlm.nih.gov/pubmed/32182359
http://dx.doi.org/10.1093/nar/gkaa164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192618/
https://www.ncbi.nlm.nih.gov/pubmed/32182359
http://dx.doi.org/10.1093/nar/gkaa164

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