Loop-closure kinetics reveal a stable, right-handed DNA intermediate in Cre recombination

In Cre site-specific recombination, the synaptic intermediate is a recombinase homotetramer containing a pair of loxP DNA target sites. The enzyme system's strand-exchange mechanism proceeds via a Holliday-junction (HJ) intermediate; however, the geometry of DNA segments in the synapse has rema...

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Detalles Bibliográficos
Autores principales: Shoura, Massa J, Giovan, Stefan M, Vetcher, Alexandre A, Ziraldo, Riccardo, Hanke, Andreas, Levene, Stephen D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192630/
https://www.ncbi.nlm.nih.gov/pubmed/32182357
http://dx.doi.org/10.1093/nar/gkaa153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192630/
https://www.ncbi.nlm.nih.gov/pubmed/32182357
http://dx.doi.org/10.1093/nar/gkaa153

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