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Loop-closure kinetics reveal a stable, right-handed DNA intermediate in Cre recombination
In Cre site-specific recombination, the synaptic intermediate is a recombinase homotetramer containing a pair of loxP DNA target sites. The enzyme system's strand-exchange mechanism proceeds via a Holliday-junction (HJ) intermediate; however, the geometry of DNA segments in the synapse has rema...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192630/ https://www.ncbi.nlm.nih.gov/pubmed/32182357 http://dx.doi.org/10.1093/nar/gkaa153 |