BCL-6 suppresses miR-142-3p/5p expression in SLE CD4(+) T cells by modulating histone methylation and acetylation of the miR-142 promoter

The reduced expression of miR-142-3p/5p in CD4(+) T cells of SLE patients caused T cell hyperactivity and B cell hyperstimulation. This study aimed to investigate the mechanisms of regulating miR-142-3p/5p expression in SLE CD4(+) T cells. The BCL-6 expression was significantly increased in SLE CD4(...

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Detalles Bibliográficos
Autores principales: Ding, Shu, Zhang, Qing, Luo, Shuangyan, Gao, Lihua, Huang, Jinhua, Lu, Jianyun, Chen, Jing, Zeng, Qinghai, Guo, Aiyuan, Zeng, Jinrong, Lu, Qianjin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192839/
https://www.ncbi.nlm.nih.gov/pubmed/31431691
http://dx.doi.org/10.1038/s41423-019-0268-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192839/
https://www.ncbi.nlm.nih.gov/pubmed/31431691
http://dx.doi.org/10.1038/s41423-019-0268-3

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