Pre-clinical activity of combined LSD1 and mTORC1 inhibition in MLL-translocated acute myeloid leukaemia

The histone demethylase lysine-specific demethylase 1 (LSD1 or KDM1A) has emerged as a candidate therapeutic target in acute myeloid leukaemia (AML); tranylcypromine-derivative inhibitors induce loss of clonogenic activity and promote differentiation, in particular in the MLL-translocated molecular...

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Detalles Bibliográficos
Autores principales: Deb, Gauri, Wingelhofer, Bettina, Amaral, Fabio M. R., Maiques-Diaz, Alba, Chadwick, John A., Spencer, Gary J., Williams, Emma L., Leong, Hui-Sun, Maes, Tamara, Somervaille, Tim C. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192845/
https://www.ncbi.nlm.nih.gov/pubmed/31780813
http://dx.doi.org/10.1038/s41375-019-0659-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192845/
https://www.ncbi.nlm.nih.gov/pubmed/31780813
http://dx.doi.org/10.1038/s41375-019-0659-6

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