Quantifying the Predictive Accuracy of a Polygenic Risk Score for Predicting Incident Cancer Cases : Application to the CARTaGENE Cohort

With the increasing use of polygenic risk scores (PRS) there is a need for adapted methods to evaluate the predictivity of these tools. In this work, we propose a new pseudo-R(2) criterion to evaluate PRS predictive accuracy for time-to-event data. This new criterion is related to the score statisti...

Descripción completa

Detalles Bibliográficos
Autores principales: Duhazé, Julianne, Jantzen, Rodolphe, Payette, Yves, De Malliard, Thibault, Labbé, Catherine, Noisel, Nolwenn, Broët, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193029/
https://www.ncbi.nlm.nih.gov/pubmed/32391062
http://dx.doi.org/10.3389/fgene.2020.00408

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193029/
https://www.ncbi.nlm.nih.gov/pubmed/32391062
http://dx.doi.org/10.3389/fgene.2020.00408

Ejemplares similares