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Integrated GWAS and mRNA Microarray Analysis Identified IFNG and CD40L as the Central Upstream Regulators in Primary Biliary Cholangitis

Genome‐wide association studies (GWASs) in European and East Asian populations have identified more than 40 disease‐susceptibility genes in primary biliary cholangitis (PBC). The aim of this study is to computationally identify disease pathways, upstream regulators, and therapeutic targets in PBC th...

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Detalles Bibliográficos
Autores principales: Ueno, Kazuko, Aiba, Yoshihiro, Hitomi, Yuki, Shimoda, Shinji, Nakamura, Hitomi, Gervais, Olivier, Kawai, Yosuke, Kawashima, Minae, Nishida, Nao, Kohn, Seik‐Soon, Kojima, Kaname, Katsushima, Shinji, Naganuma, Atsushi, Sugi, Kazuhiro, Komatsu, Tatsuji, Mannami, Tomohiko, Matsushita, Kouki, Yoshizawa, Kaname, Makita, Fujio, Nikami, Toshiki, Nishimura, Hideo, Kouno, Hiroshi, Kouno, Hirotaka, Ohta, Hajime, Komura, Takuya, Tsuruta, Satoru, Yamauchi, Kazuhiko, Kobata, Tatsuro, Kitasato, Amane, Kuroki, Tamotsu, Abiru, Seigo, Nagaoka, Shinya, Komori, Atsumasa, Yatsuhashi, Hiroshi, Migita, Kiyoshi, Ohira, Hiromasa, Tanaka, Atsushi, Takikawa, Hajime, Nagasaki, Masao, Tokunaga, Katsushi, Nakamura, Minoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193132/
https://www.ncbi.nlm.nih.gov/pubmed/32363322
http://dx.doi.org/10.1002/hep4.1497