Cargando…

Iron overload inhibits self‐renewal of human pluripotent stem cells via DNA damage and generation of reactive oxygen species

Iron overload affects the cell cycle of various cell types, but the effect of iron overload on human pluripotent stem cells has not yet been reported. Here, we show that the proliferation capacities of human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) were signific...

Descripción completa

Detalles Bibliográficos
Autores principales:	Han, Zhenbo, Xu, Zihang, Chen, Lei, Ye, Danyu, Yu, Yang, Zhang, Ying, Cao, Yang, Djibril, Bamba, Guo, Xiaofei, Gao, Xinlu, Zhang, Wenwen, Yu, Meixi, Liu, Shenzhen, Yan, Gege, Jin, Mengyu, Huang, Qi, Wang, Xiuxiu, Hua, Bingjie, Feng, Chao, Yang, Fan, Ma, Wenya, Liu, Yu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193162/ https://www.ncbi.nlm.nih.gov/pubmed/32053740 http://dx.doi.org/10.1002/2211-5463.12811

Ejemplares similares

ALKBH5 regulates cardiomyocyte proliferation and heart regeneration by demethylating the mRNA of YTHDF1
por: Han, Zhenbo, et al.
Publicado: (2021)

ALKBH5-mediated m(6)A mRNA methylation governs human embryonic stem cell cardiac commitment
por: Han, Zhenbo, et al.
Publicado: (2021)

Inhibition of iron overload-induced apoptosis and necrosis of bone marrow mesenchymal stem cells by melatonin
por: Yang, Fan, et al.
Publicado: (2017)

Synergistic anti-tumor effects of arsenic trioxide and blue LED irradiation on human osteosarcoma
por: Feng, Chao, et al.
Publicado: (2019)

miR-149-3p Regulates the Switch between Adipogenic and Osteogenic Differentiation of BMSCs by Targeting FTO
por: Li, Yuan, et al.
Publicado: (2019)

WDR36 Safeguards Self-Renewal and Pluripotency of Human Extended Pluripotent Stem Cells
por: An, Shiyu, et al.
Publicado: (2022)

By Targeting Atg7 MicroRNA-143 Mediates Oxidative Stress-Induced Autophagy of c-Kit(+) Mouse Cardiac Progenitor Cells
por: Ma, Wenya, et al.
Publicado: (2018)

m(6)A Methylation of Precursor-miR-320/RUNX2 Controls Osteogenic Potential of Bone Marrow-Derived Mesenchymal Stem Cells
por: Yan, Gege, et al.
Publicado: (2019)

Photobiomodulation Drives MiR-136-5p Expression to Promote Injury Repair after Myocardial Infarction
por: Gao, Xinlu, et al.
Publicado: (2022)

Blue LED causes autophagic cell death in human osteosarcoma by increasing ROS generation and dephosphorylating EGFR
por: He, Mingyu, et al.
Publicado: (2021)

Induced hepatic stem cells maintain self-renewal through the high expression of Myc coregulated by TET1 and CTCF
por: Wang, Chen, et al.
Publicado: (2022)

Photobiomodulation Regulation as One Promising Therapeutic Approach for Myocardial Infarction
por: Gao, Xinlu, et al.
Publicado: (2021)

Pluripotency-State-Dependent Role of Dax1 in Embryonic Stem Cells Self-Renewal
por: He, Jianrong, et al.
Publicado: (2021)

Dppa3 facilitates self-renewal of embryonic stem cells by stabilization of pluripotent factors
por: Zhao, Shuang, et al.
Publicado: (2022)

MicroRNA‐92b‐5p modulates melatonin‐mediated osteogenic differentiation of bone marrow mesenchymal stem cells by targeting ICAM‐1
por: Li, Yuan, et al.
Publicado: (2019)

EGFR deficiency leads to impaired self-renewal and pluripotency of mouse embryonic stem cells
por: Yu, Miaoying, et al.
Publicado: (2019)

Light Emitting Diodes Photobiomodulation Improves Cardiac Function by Promoting ATP Synthesis in Mice With Heart Failure
por: Zhang, Wenwen, et al.
Publicado: (2021)

Cyclin L1 controls cardiomyocyte proliferation and heart repair after injury
por: Gong, Rui, et al.
Publicado: (2023)

Feeder cells treated with ethanol can be used to maintain self‐renewal and pluripotency of human pluripotent stem cells
por: Ren, Yahui, et al.
Publicado: (2023)

Modaline sulfate promotes Oct4 expression and maintains self-renewal and pluripotency of stem cells through JAK/STAT3 and Wnt signaling pathways
por: Mei, Xianglin, et al.
Publicado: (2021)

Light Emitting Diodes Irradiation Regulates miRNA-877-3p to Promote Cardiomyocyte Proliferation
por: Gao, Xinlu, et al.
Publicado: (2022)

The long non-coding RNA Snhg3 is essential for mouse embryonic stem cell self-renewal and pluripotency
por: Lu, Weisi, et al.
Publicado: (2019)

The Function of E-Cadherin in Stem Cell Pluripotency and Self-Renewal
por: Soncin, Francesca, et al.
Publicado: (2011)

Maxadilan Prevents Apoptosis in iPS Cells and Shows No Effects on the Pluripotent State or Karyotype
por: Zhao, Zhiyi, et al.
Publicado: (2012)

Downregulated developmental processes in the postnatal right ventricle under the influence of a volume overload
por: Zhou, Chunxia, et al.
Publicado: (2021)

Musashi2 Is Required for the Self-Renewal and Pluripotency of Embryonic Stem Cells
por: Wuebben, Erin L., et al.
Publicado: (2012)

Molecular Basis of Mammalian Embryonic Stem Cell Pluripotency and Self-Renewal
por: Medvedev, S.P., et al.
Publicado: (2010)

NPR-A regulates self-renewal and pluripotency of embryonic stem cells
por: Abdelalim, E M, et al.
Publicado: (2011)

Doxycycline Enhances Survival and Self-Renewal of Human Pluripotent Stem Cells
por: Chang, Mi-Yoon, et al.
Publicado: (2014)

A Stem Cell Reporter for Investigating Pluripotency and Self-Renewal in the Rat
por: Meek, Stephen, et al.
Publicado: (2020)

Enhanced self-renewal of human pluripotent stem cells by simulated microgravity
por: Timilsina, S., et al.
Publicado: (2022)

Molecular Mechanisms Underlying Pluripotency and Self-Renewal of Embryonic Stem Cells
por: Varzideh, Fahimeh, et al.
Publicado: (2023)

Wnt/β-catenin signaling pathway is activated in the progress of mandibular condylar cartilage degeneration and subchondral bone loss induced by overloaded functional orthopedic force (OFOF)
por: He, Zijing, et al.
Publicado: (2022)

A Novel Star Like Eight-Arm Polyethylene Glycol-Deferoxamine Conjugate for Iron Overload Therapy
por: Yu, Bohong, et al.
Publicado: (2020)

Exogenous LIN28 Is Required for the Maintenance of Self-Renewal and Pluripotency in Presumptive Porcine-Induced Pluripotent Stem Cells
por: Chakritbudsabong, Warunya, et al.
Publicado: (2021)

Clustering-local-unique-enriched-signals (CLUES) promotes identification of novel regulators of ES cell self-renewal and pluripotency
por: Wu, Chao, et al.
Publicado: (2018)

New Deferric Amine Compounds Efficiently Chelate Excess Iron to Treat Iron Overload Disorders and to Prevent Ferroptosis
por: Feng, Wenya, et al.
Publicado: (2022)

Can Goal-Based Health Management Improve the Health Knowledge, Health Belief and Health Behavior in People at High Risk of Stroke? A Non-Randomized Controlled Trial
por: He, Yu, et al.
Publicado: (2021)

Phosphorylation of ULK1 by AMPK is essential for mouse embryonic stem cell self-renewal and pluripotency
por: Gong, Jiaqi, et al.
Publicado: (2018)

Rethinking of Alzheimer's disease: Lysosomal overloading and dietary therapy
por: Yuan, Shu, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_teahf0ssunh4h5g6mm82j14ueb