Development of a novel murine heart failure model overexpressing human renin and angiotensinogen

Renin is the rate‐limiting enzyme of the renin–angiotensin system cascade, which drives the pathophysiological progression of heart failure. Species differences in the amino acid sequence of the catalytic domain of renin limit evaluations of the potency and efficacy of human renin inhibitors in anim...

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Detalles Bibliográficos
Autores principales: Hara, Tomoya, Yamamura, Takeshi, Murakami‐Asahina, Mirei, Matsumoto, Hirokazu, Takeyama, Michiyasu, Kanagawa, Ray, Nishimoto, Tomoyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193172/
https://www.ncbi.nlm.nih.gov/pubmed/32056390
http://dx.doi.org/10.1002/2211-5463.12810

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193172/
https://www.ncbi.nlm.nih.gov/pubmed/32056390
http://dx.doi.org/10.1002/2211-5463.12810

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