IL6R-STAT3-ADAR1 (P150) interplay promotes oncogenicity in multiple myeloma with 1q21 amplification

1q21 amplification is an important prognostic marker in multiple myeloma. In this study we identified that IL6R (the interleukin-6 membrane receptor) and ADAR1 (an RNA editing enzyme) are critical genes located within the minimally amplified 1q21 region. Loss of individual genes caused suppression t...

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Detalles Bibliográficos
Autores principales: Teoh, Phaik Ju, Chung, Tae-Hoon, Chng, Pamela Y.Z., Toh, Sabrina H. M., Chng, Wee Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193471/
https://www.ncbi.nlm.nih.gov/pubmed/31413087
http://dx.doi.org/10.3324/haematol.2019.221176

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193471/
https://www.ncbi.nlm.nih.gov/pubmed/31413087
http://dx.doi.org/10.3324/haematol.2019.221176

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