Prion protein deficiency impairs hematopoietic stem cell determination and sensitizes myeloid progenitors to irradiation

Highly conserved among species and expressed in various types of cells, numerous roles have been attributed to the cellular prion protein (PrPC). In hematopoiesis, PrPC regulates hematopoietic stem cell self-renewal but the mechanisms involved in this regulation are unknown. Here we show that PrPC r...

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Detalles Bibliográficos
Autores principales: Siberchicot, Capucine, Gault, Nathalie, Déchamps, Nathalie, Barroca, Vilma, Aguzzi, Adriano, Roméo, Paul-Henri, Radicella, J. Pablo, Bravard, Anne, Bernardino-Sgherri, Jacqueline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193476/
https://www.ncbi.nlm.nih.gov/pubmed/31371412
http://dx.doi.org/10.3324/haematol.2018.205716

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193476/
https://www.ncbi.nlm.nih.gov/pubmed/31371412
http://dx.doi.org/10.3324/haematol.2018.205716

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