Oncogenic fusion protein BCR-FGFR1 requires the breakpoint cluster region-mediated oligomerization and chaperonin Hsp90 for activation

Mutation and translocation of fibroblast growth factor receptors often lead to aberrant signaling and cancer. This work focuses on the t(8;22)(p11;q11) chromosomal translocation which creates the breakpoint cluster region (BCR) fibroblast growth factor receptor1 (FGFR1) (BCR-FGFR1) fusion protein. T...

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Detalles Bibliográficos
Autores principales: Peiris, Malalage N., Meyer, April N., Nelson, Katelyn N., Bisom-Rapp, Ezra W., Donoghue, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193502/
https://www.ncbi.nlm.nih.gov/pubmed/31439673
http://dx.doi.org/10.3324/haematol.2019.220871

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193502/
https://www.ncbi.nlm.nih.gov/pubmed/31439673
http://dx.doi.org/10.3324/haematol.2019.220871

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