Cargando…

Oncogenic fusion protein BCR-FGFR1 requires the breakpoint cluster region-mediated oligomerization and chaperonin Hsp90 for activation

Mutation and translocation of fibroblast growth factor receptors often lead to aberrant signaling and cancer. This work focuses on the t(8;22)(p11;q11) chromosomal translocation which creates the breakpoint cluster region (BCR) fibroblast growth factor receptor1 (FGFR1) (BCR-FGFR1) fusion protein. T...

Descripción completa

Detalles Bibliográficos
Autores principales:	Peiris, Malalage N., Meyer, April N., Nelson, Katelyn N., Bisom-Rapp, Ezra W., Donoghue, Daniel J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ferrata Storti Foundation 2020
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193502/ https://www.ncbi.nlm.nih.gov/pubmed/31439673 http://dx.doi.org/10.3324/haematol.2019.220871

Ejemplares similares

Oncogenic fusion protein FGFR2-PPHLN1: Requirements for biological activation, and efficacy of inhibitors
por: Li, Fangda, et al.
Publicado: (2020)

Oncogenic driver FGFR3-TACC3 requires five coiled-coil heptads for activation and disulfide bond formation for stability
por: Wang, Clark G., et al.
Publicado: (2023)

Proteomic analysis reveals dual requirement for Grb2 and PLCγ1 interactions for BCR-FGFR1-Driven 8p11 cell proliferation
por: Peiris, Malalage N., et al.
Publicado: (2022)

BCR: a promiscuous fusion partner in hematopoietic disorders
por: Peiris, Malalage N., et al.
Publicado: (2019)

Oncogenic driver FGFR3-TACC3 is dependent on membrane trafficking and ERK signaling
por: Nelson, Katelyn N., et al.
Publicado: (2018)

HSP90 inhibitor AUY922 induces cell death by disruption of the Bcr-Abl, Jak2 and HSP90 signaling network complex in leukemia cells
por: Tao, Wenjing, et al.
Publicado: (2015)

Chaperonin of Group I: Oligomeric Spectrum and Biochemical and Biological Implications
por: Vilasi, Silvia, et al.
Publicado: (2018)

The HSP90 inhibitor KW-2478 depletes the malignancy of BCR/ABL and overcomes the imatinib-resistance caused by BCR/ABL amplification
por: Zeng, Dachuan, et al.
Publicado: (2022)

Complex Destabilization in the Mitochondrial Chaperonin Hsp60 Leads to Disease
por: Rodriguez, Alejandro, et al.
Publicado: (2020)

Targeting the MYC Oncogene in Burkitt Lymphoma through HSP90 Inhibition
por: Poole, Candace J., et al.
Publicado: (2018)

Intraring allostery controls the function and assembly of a hetero-oligomeric class II chaperonin
por: Shoemark, Deborah K., et al.
Publicado: (2018)

Retraction Note: Disruption of the Bcr-Abl/Hsp90 protein complex: a possible mechanism to inhibit Bcr-Abl-positive human leukemic blasts by novobiocin
por: Wu, L. X., et al.
Publicado: (2020)

Oncogenic HSP90 Facilitates Metabolic Alterations in Aggressive B-cell Lymphomas
por: Calvo-Vidal, M. Nieves, et al.
Publicado: (2021)

Functional characterization of two rare BCR–FGFR1(+) leukemias
por: Barnes, Evan J., et al.
Publicado: (2020)

Role of the chaperonin cofactor Hsp10 in protein folding and sorting in yeast mitochondria
Publicado: (1994)

Identification of Elements That Dictate the Specificity of Mitochondrial Hsp60 for Its Co-Chaperonin
por: Parnas, Avital, et al.
Publicado: (2012)

Structural basis for the structural dynamics of human mitochondrial chaperonin mHsp60
por: Wang, Joseph Che-Yen, et al.
Publicado: (2021)

Structural basis for active single and double ring complexes in human mitochondrial Hsp60-Hsp10 chaperonin
por: Gomez-Llorente, Yacob, et al.
Publicado: (2020)

BCR/ABL1 and BCR are under the transcriptional control of the MYC oncogene
por: Sharma, Nitesh, et al.
Publicado: (2015)

Characterization of FGFR signaling in prostate cancer stem cells and inhibition via TKI treatment
por: Ko, Juyeon, et al.
Publicado: (2021)

Hsp90 N- and C-terminal double inhibition synergistically suppresses Bcr-Abl-positive human leukemia cells
por: Chen, Chun, et al.
Publicado: (2016)

Comparative Expression Analysis of Breakpoint Cluster Region–Abelson Oncogene in Leukemia Patients
por: Arshad, Farah, et al.
Publicado: (2023)

Conserved and divergent chaperoning effects of Hsp60/10 chaperonins on protein folding landscapes
por: Sadat, Anwar, et al.
Publicado: (2022)

Crystal structures of dimeric and heptameric mtHsp60 reveal the mechanism of chaperonin inactivation
por: Lai, Meng-Cheng, et al.
Publicado: (2023)

Impact of the Breakpoint Region on the Leukemogenic Potential and the TKI Responsiveness of Atypical BCR-ABL1 Transcripts
por: Massimino, Michele, et al.
Publicado: (2021)

Probing the interface in a human co-chaperonin heptamer: residues disrupting oligomeric unfolded state identified
por: Guidry, Jesse J, et al.
Publicado: (2003)

Functional Exploration of Chaperonin (HSP60/10) Family Genes and their Abiotic Stress-induced Expression Patterns in Sorghum bicolor
por: Nagaraju, M., et al.
Publicado: (2021)

Disease-Associated Mutations in the HSPD1 Gene Encoding the Large Subunit of the Mitochondrial HSP60/HSP10 Chaperonin Complex
por: Bross, Peter, et al.
Publicado: (2016)

RNAi technology targeting the FGFR3-TACC3 fusion breakpoint: an opportunity for precision medicine
por: Parker Kerrigan, Brittany C, et al.
Publicado: (2020)

Cell surface heparan sulfate proteoglycans are involved in the binding of Hsp90α and Hsp90β to the cell plasma membrane
por: Snigireva, Anastasiya V, et al.
Publicado: (2015)

Chaperonin (HSP60) and annexin-2 are candidate biomarkers for non-small cell lung carcinoma
por: Ağababaoğlu, İsmail, et al.
Publicado: (2017)

Publisher Correction: Structural basis for the structural dynamics of human mitochondrial chaperonin mHsp60
por: Wang, Joseph Che-Yen, et al.
Publicado: (2021)

Asymmetric apical domain states of mitochondrial Hsp60 coordinate substrate engagement and chaperonin assembly
por: Braxton, Julian R., et al.
Publicado: (2023)

Disease Variants of FGFR3 Reveal Molecular Basis for the Recognition and Additional Roles for Cdc37 in Hsp90 Chaperone System
por: Bunney, Tom D., et al.
Publicado: (2018)

Oligomeric State and Holding Activity of Hsp60
por: Caruso Bavisotto, Celeste, et al.
Publicado: (2023)

Circulating heat shock protein 90 (Hsp90) and autoantibodies to Hsp90 are increased in patients with atopic dermatitis
por: Sitko, Krzysztof, et al.
Publicado: (2021)

The Receptor Tyrosine Kinase FGFR4 Negatively Regulates NF-kappaB Signaling
por: Drafahl, Kristine A., et al.
Publicado: (2010)

Y‐632 inhibits heat shock protein 90 (Hsp90) function by disrupting the interaction between Hsp90 and Hsp70/Hsp90 organizing protein, and exerts antitumor activity in vitro and in vivo
por: Wang, Wenqian, et al.
Publicado: (2016)

The anti-oncogenic effect of 17-DMAG via the inactivation of HSP90 and MET pathway in osteosarcoma cells
por: KAWANO, MASANORI, et al.
Publicado: (2023)

A function for the mitochondrial chaperonin Hsp60 in the structure and transmission of mitochondrial DNA nucleoids in Saccharomyces cerevisiae
por: Kaufman, Brett A., et al.
Publicado: (2003)

Cannot write session to /tmp/vufind_sessions/sess_l54ckv0n1p6a931v08c40vj5kl