Targeted analysis of polymorphic loci from low-coverage shotgun sequence data allows accurate genotyping of HLA genes in historical human populations

The highly polymorphic human leukocyte antigen (HLA) plays a crucial role in adaptive immunity and is associated with various complex diseases. Accurate analysis of HLA genes using ancient DNA (aDNA) data is crucial for understanding their role in human adaptation to pathogens. Here, we describe the...

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Detalles Bibliográficos
Autores principales: Pierini, Federica, Nutsua, Marcel, Böhme, Lisa, Özer, Onur, Bonczarowska, Joanna, Susat, Julian, Franke, Andre, Nebel, Almut, Krause-Kyora, Ben, Lenz, Tobias L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193575/
https://www.ncbi.nlm.nih.gov/pubmed/32355290
http://dx.doi.org/10.1038/s41598-020-64312-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193575/
https://www.ncbi.nlm.nih.gov/pubmed/32355290
http://dx.doi.org/10.1038/s41598-020-64312-w

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