Positron emission tomography imaging of novel AAV capsids maps rapid brain accumulation

Adeno-associated viruses (AAVs) are typically single-stranded deoxyribonucleic acid (ssDNA) encapsulated within 25-nm protein capsids. Recently, tissue-specific AAV capsids (e.g. PHP.eB) have been shown to enhance brain delivery in rodents via the LY6A receptor on brain endothelial cells. Here, we c...

Descripción completa

Detalles Bibliográficos
Autores principales: Seo, Jai Woong, Ingham, Elizabeth S., Mahakian, Lisa, Tumbale, Spencer, Wu, Bo, Aghevlian, Sadaf, Shams, Shahin, Baikoghli, Mo, Jain, Poorva, Ding, Xiaozhe, Goeden, Nick, Dobreva, Tatyana, Flytzanis, Nicholas C., Chavez, Michael, Singhal, Kratika, Leib, Ryan, James, Michelle L., Segal, David J., Cheng, R. Holland, Silva, Eduardo A., Gradinaru, Viviana, Ferrara, Katherine W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193641/
https://www.ncbi.nlm.nih.gov/pubmed/32355221
http://dx.doi.org/10.1038/s41467-020-15818-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193641/
https://www.ncbi.nlm.nih.gov/pubmed/32355221
http://dx.doi.org/10.1038/s41467-020-15818-4

Ejemplares similares