ErCas12a CRISPR-MAD7 for Model Generation in Human Cells, Mice, and Rats

MAD7 is an engineered class 2 type V-A CRISPR-Cas (Cas12a/Cpf1) system isolated from Eubacterium rectale. Analogous to Cas9, it is an RNA-guided nuclease with demonstrated gene editing activity in Escherichia coli and yeast cells. Here, we report that MAD7 is capable of generating indels and fluores...

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Detalles Bibliográficos
Autores principales: Liu, Zhenyi, Schiel, John A., Maksimova, Elena, Strezoska, Žaklina, Zhao, Guojun, Anderson, Emily M., Wu, Yumei, Warren, Joe, Bartels, Angela, van Brabant Smith, Anja, Lowe, Chris E., Forbes, Kevin P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194332/
https://www.ncbi.nlm.nih.gov/pubmed/32315227
http://dx.doi.org/10.1089/crispr.2019.0068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194332/
https://www.ncbi.nlm.nih.gov/pubmed/32315227
http://dx.doi.org/10.1089/crispr.2019.0068

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