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Investigating the effect of dependence between conditions with Bayesian Linear Mixed Models for motif activity analysis

MOTIVATION: Cellular identity and behavior is controlled by complex gene regulatory networks. Transcription factors (TFs) bind to specific DNA sequences to regulate the transcription of their target genes. On the basis of these TF motifs in cis-regulatory elements we can model the influence of TFs o...

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Detalles Bibliográficos
Autores principales: Lederer, Simone, Heskes, Tom, van Heeringen, Simon J., Albers, Cornelis A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194367/
https://www.ncbi.nlm.nih.gov/pubmed/32357166
http://dx.doi.org/10.1371/journal.pone.0231824