Cargando…
Site-Specific Photo-Crosslinking Proteomics Reveal Regulation of IFITM3 Trafficking and Turnover by VCP/p97 ATPase
Interferon-induced transmembrane protein 3 (IFITM3) is a key interferon effector that broadly prevents infection by diverse viruses. However, the cellular factors that control IFITM3 homeostasis and antiviral activity have not been fully elucidated. Using site-specific photo-crosslinking and quantit...
Autores principales: | Wu, Xiaojun, Spence, Jennifer S., Das, Tandrila, Yuan, Xiaoqiu, Chen, Chengjie, Zhang, Yuqing, Li, Yumeng, Sun, Yanan, Chandran, Kartik, Hang, Howard C., Peng, Tao |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Ltd.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194980/ https://www.ncbi.nlm.nih.gov/pubmed/32243810 http://dx.doi.org/10.1016/j.chembiol.2020.03.004 |
Ejemplares similares
-
Ubiquitin-directed AAA+ ATPase p97/VCP unfolds stable proteins crosslinked to DNA for proteolysis by SPRTN
por: Kröning, Alexander, et al.
Publicado: (2022) -
IFITM3 directly engages and shuttles incoming virus particles to lysosomes
por: Spence, Jennifer S., et al.
Publicado: (2019) -
The Role of the N-Domain in the ATPase Activity of the Mammalian AAA ATPase p97/VCP
por: Niwa, Hajime, et al.
Publicado: (2012) -
How Viruses Use the VCP/p97 ATPase Molecular Machine
por: Das, Poulami, et al.
Publicado: (2021) -
S-palmitoylation and sterol interactions mediate antiviral specificity of IFITM isoforms
por: Das, Tandrila, et al.
Publicado: (2021)