Importance of γ-secretase in the regulation of liver X receptor and cellular lipid metabolism

Presenilins (PS) are the catalytic components of γ-secretase complexes that mediate intramembrane proteolysis. Mutations in the PS genes are a major cause of familial early-onset Alzheimer disease and affect the cleavage of the amyloid precursor protein, thereby altering the production of the amyloi...

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Detalles Bibliográficos
Autores principales: Gutierrez, Esteban, Lütjohann, Dieter, Kerksiek, Anja, Fabiano, Marietta, Oikawa, Naoto, Kuerschner, Lars, Thiele, Christoph, Walter, Jochen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195048/
https://www.ncbi.nlm.nih.gov/pubmed/32354700
http://dx.doi.org/10.26508/lsa.201900521

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195048/
https://www.ncbi.nlm.nih.gov/pubmed/32354700
http://dx.doi.org/10.26508/lsa.201900521

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