Augmentation of brain tumor interstitial flow via focused ultrasound promotes brain-penetrating nanoparticle dispersion and transfection

The delivery of systemically administered gene therapies to brain tumors is exceptionally difficult because of the blood-brain barrier (BBB) and blood-tumor barrier (BTB). In addition, the adhesive and nanoporous tumor extracellular matrix hinders therapeutic dispersion. We first developed the use o...

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Detalles Bibliográficos
Autores principales: Curley, Colleen T., Mead, Brian P., Negron, Karina, Kim, Namho, Garrison, William J., Miller, G. Wilson, Kingsmore, Kathryn M., Thim, E. Andrew, Song, Ji, Munson, Jennifer M., Klibanov, Alexander L., Suk, Jung Soo, Hanes, Justin, Price, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195188/
https://www.ncbi.nlm.nih.gov/pubmed/32494662
http://dx.doi.org/10.1126/sciadv.aay1344

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195188/
https://www.ncbi.nlm.nih.gov/pubmed/32494662
http://dx.doi.org/10.1126/sciadv.aay1344

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