Cargando…
Augmentation of brain tumor interstitial flow via focused ultrasound promotes brain-penetrating nanoparticle dispersion and transfection
The delivery of systemically administered gene therapies to brain tumors is exceptionally difficult because of the blood-brain barrier (BBB) and blood-tumor barrier (BTB). In addition, the adhesive and nanoporous tumor extracellular matrix hinders therapeutic dispersion. We first developed the use o...
Autores principales: | Curley, Colleen T., Mead, Brian P., Negron, Karina, Kim, Namho, Garrison, William J., Miller, G. Wilson, Kingsmore, Kathryn M., Thim, E. Andrew, Song, Ji, Munson, Jennifer M., Klibanov, Alexander L., Suk, Jung Soo, Hanes, Justin, Price, Richard J. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195188/ https://www.ncbi.nlm.nih.gov/pubmed/32494662 http://dx.doi.org/10.1126/sciadv.aay1344 |
Ejemplares similares
-
Sonoselective transfection of cerebral vasculature without blood–brain barrier disruption
por: Gorick, Catherine M., et al.
Publicado: (2020) -
Transcriptomic response of brain tissue to focused ultrasound‐mediated blood–brain barrier disruption depends strongly on anesthesia
por: Mathew, Alexander S., et al.
Publicado: (2020) -
MRI analysis to map interstitial flow in the brain tumor microenvironment
por: Kingsmore, Kathryn M., et al.
Publicado: (2018) -
Ultrasound-mediated delivery of brain-penetrating nanoparticles across the blood-tumor barrier
por: Timbie, Kelsie, et al.
Publicado: (2015) -
Single-cell mapping of focused ultrasound-transfected brain
por: Mathew, A. S., et al.
Publicado: (2021)