Attenuated diphtheria toxin mediates siRNA delivery

Toxins efficiently deliver cargo to cells by binding to cell surface ligands, initiating endocytosis, and escaping the endolysosomal pathway into the cytoplasm. We took advantage of this delivery pathway by conjugating an attenuated diphtheria toxin to siRNA, thereby achieving gene downregulation in...

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Detalles Bibliográficos
Autores principales: Arnold, Amy E., Smith, Laura J., Beilhartz, Greg L., Bahlmann, Laura C., Jameson, Emma, Melnyk, Roman A., Shoichet, Molly S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195190/
https://www.ncbi.nlm.nih.gov/pubmed/32917630
http://dx.doi.org/10.1126/sciadv.aaz4848

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195190/
https://www.ncbi.nlm.nih.gov/pubmed/32917630
http://dx.doi.org/10.1126/sciadv.aaz4848

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