Non-catalytic ubiquitin binding by A20 prevents psoriatic arthritis-like disease and inflammation

A20 is an anti-inflammatory protein that is strongly linked to human disease. Here we find that mice expressing three distinct targeted mutations of A20’s ZF7 ubiquitin binding motif uniformly developed digit arthritis that shares features with psoriatic arthritis, while mice expressing point mutati...

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Detalles Bibliográficos
Autores principales: Razani, Bahram, Whang, Michael I., Kim, Francis S., Nakamura, Mary C., Sun, Xiaofei, Advincula, Rommel, Turnbaugh, Jessie A., Pendse, Mihir, Tanbun, Priscilia, Achacoso, Philip, Turnbaugh, Peter J., Malynn, Barbara A., Ma, Averil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195210/
https://www.ncbi.nlm.nih.gov/pubmed/32205880
http://dx.doi.org/10.1038/s41590-020-0634-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195210/
https://www.ncbi.nlm.nih.gov/pubmed/32205880
http://dx.doi.org/10.1038/s41590-020-0634-4

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