A modular biomimetic strategy for the synthesis of macrolide P-glycoprotein inhibitors via Rh-catalyzed C-H activation

One of the key challenges to overcome multidrug resistance (MDR) in cancer is the development of more effective and general strategies to discover bioactive scaffolds. Inspired by natural products, we describe a strategy to achieve this goal by modular biomimetic synthesis of scaffolds of (Z)-allyli...

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Detalles Bibliográficos
Autores principales: Chen, Lu, Quan, Haitian, Xu, Zhongliang, Wang, Hao, Xia, Yuanzhi, Lou, Liguang, Yang, Weibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195407/
https://www.ncbi.nlm.nih.gov/pubmed/32358512
http://dx.doi.org/10.1038/s41467-020-16084-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195407/
https://www.ncbi.nlm.nih.gov/pubmed/32358512
http://dx.doi.org/10.1038/s41467-020-16084-0

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