PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma

A non-immunogenic tumor microenvironment (TME) is a significant barrier to immune checkpoint blockade (ICB) response. The impact of Polybromo-1 (PBRM1) on TME and response to ICB in renal cell carcinoma (RCC) remains to be resolved. Here we show that PBRM1/Pbrm1 deficiency reduces the binding of bra...

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Detalles Bibliográficos
Autores principales: Liu, Xian-De, Kong, Wen, Peterson, Christine B., McGrail, Daniel J., Hoang, Anh, Zhang, Xuesong, Lam, Truong, Pilie, Patrick G., Zhu, Haifeng, Beckermann, Kathryn E., Haake, Scott M., Isgandrova, Sevinj, Martinez-Moczygemba, Margarita, Sahni, Nidhi, Tannir, Nizar M., Lin, Shiaw-Yih, Rathmell, W. Kimryn, Jonasch, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195420/
https://www.ncbi.nlm.nih.gov/pubmed/32358509
http://dx.doi.org/10.1038/s41467-020-15959-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195420/
https://www.ncbi.nlm.nih.gov/pubmed/32358509
http://dx.doi.org/10.1038/s41467-020-15959-6

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