Single-cell expression and Mendelian randomization analyses identify blood genes associated with lifespan and chronic diseases

The human lifespan is a heritable trait, which is intricately linked to the development of disorders. Here, we show that genetic associations for the parental lifespan are enriched in open chromatin of blood cells. By using blood expression quantitative trait loci (eQTL) derived from 31,684 samples,...

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Detalles Bibliográficos
Autores principales: Chignon, Arnaud, Bon-Baret, Valentin, Boulanger, Marie-Chloé, Li, Zhonglin, Argaud, Deborah, Bossé, Yohan, Thériault, Sébastien, Arsenault, Benoit J., Mathieu, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195437/
https://www.ncbi.nlm.nih.gov/pubmed/32358504
http://dx.doi.org/10.1038/s42003-020-0937-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195437/
https://www.ncbi.nlm.nih.gov/pubmed/32358504
http://dx.doi.org/10.1038/s42003-020-0937-x

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