Mutational signatures are jointly shaped by DNA damage and repair

Cells possess an armamentarium of DNA repair pathways to counter DNA damage and prevent mutation. Here we use C. elegans whole genome sequencing to systematically quantify the contributions of these factors to mutational signatures. We analyse 2,717 genomes from wild-type and 53 DNA repair defective...

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Detalles Bibliográficos
Autores principales: Volkova, Nadezda V., Meier, Bettina, González-Huici, Víctor, Bertolini, Simone, Gonzalez, Santiago, Vöhringer, Harald, Abascal, Federico, Martincorena, Iñigo, Campbell, Peter J., Gartner, Anton, Gerstung, Moritz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195458/
https://www.ncbi.nlm.nih.gov/pubmed/32358516
http://dx.doi.org/10.1038/s41467-020-15912-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195458/
https://www.ncbi.nlm.nih.gov/pubmed/32358516
http://dx.doi.org/10.1038/s41467-020-15912-7

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