Ubiquitinated-PCNA protects replication forks from DNA2-mediated degradation by regulating Okazaki fragment maturation and chromatin assembly

Upon genotoxic stress, PCNA ubiquitination allows for replication of damaged DNA by recruiting lesion-bypass DNA polymerases. However, PCNA is also ubiquitinated during normal S-phase progression. By employing 293T and RPE1 cells deficient in PCNA ubiquitination, generated through CRISPR/Cas9 gene e...

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Detalles Bibliográficos
Autores principales: Thakar, Tanay, Leung, Wendy, Nicolae, Claudia M., Clements, Kristen E., Shen, Binghui, Bielinsky, Anja-Katrin, Moldovan, George-Lucian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195461/
https://www.ncbi.nlm.nih.gov/pubmed/32358495
http://dx.doi.org/10.1038/s41467-020-16096-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195461/
https://www.ncbi.nlm.nih.gov/pubmed/32358495
http://dx.doi.org/10.1038/s41467-020-16096-w

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