Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer’s disease

Mitochondria contribute to shape intraneuronal Ca(2+) signals. Excessive Ca(2+) taken up by mitochondria could lead to cell death. Amyloid beta (Aβ) causes cytosolic Ca(2+) overload, but the effects of Aβ on mitochondrial Ca(2+) levels in Alzheimer’s disease (AD) remain unclear. Using a ratiometric...

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Detalles Bibliográficos
Autores principales: Calvo-Rodriguez, Maria, Hou, Steven S., Snyder, Austin C., Kharitonova, Elizabeth K., Russ, Alyssa N., Das, Sudeshna, Fan, Zhanyun, Muzikansky, Alona, Garcia-Alloza, Monica, Serrano-Pozo, Alberto, Hudry, Eloise, Bacskai, Brian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195480/
https://www.ncbi.nlm.nih.gov/pubmed/32358564
http://dx.doi.org/10.1038/s41467-020-16074-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195480/
https://www.ncbi.nlm.nih.gov/pubmed/32358564
http://dx.doi.org/10.1038/s41467-020-16074-2

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