Seasonal changes in NRF2 antioxidant pathway regulates winter depression-like behavior

Seasonal changes in the environment lead to depression-like behaviors in humans and animals. The underlying mechanisms, however, are unknown. We observed decreased sociability and increased anxiety-like behavior in medaka fish exposed to winter-like conditions. Whole brain metabolomic analysis revea...

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Detalles Bibliográficos
Autores principales: Nakayama, Tomoya, Okimura, Kousuke, Shen, Jiachen, Guh, Ying-Jey, Tamai, T. Katherine, Shimada, Akiko, Minou, Souta, Okushi, Yuki, Shimmura, Tsuyoshi, Furukawa, Yuko, Kadofusa, Naoya, Sato, Ayato, Nishimura, Toshiya, Tanaka, Minoru, Nakayama, Kei, Shiina, Nobuyuki, Yamamoto, Naoyuki, Loudon, Andrew S., Nishiwaki-Ohkawa, Taeko, Shinomiya, Ai, Nabeshima, Toshitaka, Nakane, Yusuke, Yoshimura, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196813/
https://www.ncbi.nlm.nih.gov/pubmed/32277035
http://dx.doi.org/10.1073/pnas.2000278117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196813/
https://www.ncbi.nlm.nih.gov/pubmed/32277035
http://dx.doi.org/10.1073/pnas.2000278117

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